Bulk quantities of Rat APRIL protein are available.
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Molecular Weight (calculated) - 16.4kDa
Amino Acid Sequence - AVLTQKHKKK QSVLHLVPIN ITSKADSDMT EVMWQPALRR GRGLEAQGDT VRVRDTGIYL LYSQVLFHDV TFTMGQVVSR EGQGRRETLF RCIKSMPSDP DRAYNSCYSA GVFHLHQGDI ITVKIPRANA KLSLSPHGTF LGFVKL (146)
Gene ID - 287437
Homology Across Species
Rattus norvegicus (Norway rat) APRIL – 100%
Rattus rattus (black rat) APRIL – 99%
More - https://blast.ncbi.nlm.nih.gov/
Endotoxin - Naturally endotoxin-free
Cell Culture, ELISA Standard, Western Blot Control
Tumor necrosis factor ligand superfamily member 13 (TNFSF13) also known as a proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor ligand (TNF) ligand family. Nineteen cytokines have been identified as part of the TNF family on the basis of sequence, functional, and structural similarities. Family members include TNF beta (TNFSF1), TNF alpha (TNFSF2), Lymphotoxin beta (TNFSF3), OX40 Ligand (TNFSF4), CD40 Ligand (TNFSF5), Fas Ligand (TNFSF6), CD27 Ligand (TNFSF7), CD30 Ligand (TNFSF8), 4-1BB Ligand (TNFSF9), TRAIL (TNFSF10), TRANCE/RANKL (TNFSF11), TWEAK (TNFSF12), APRIL(TNFSF13), BAFF (TNFSF13B), LIGHT (TNFSF14), TL1A/VEGI (TNFSF15), and GITR Ligand (TNFSF18). APRIL/TNFSF13 is expressed by macrophages and dendritic cells. APRIL/TNFSF13 has been shown to play a role in protecting cells from undergoing apoptosis and promoting B cell development.
Alternate Names - TNFSF13, APRIL, CD256, TALL-2, TALL2, TRDL-1, ZTNF2, UNQ383/PRO715, TNLG7B, tumor necrosis factor superfamily member 13, TNF superfamily member 13
APRIL promotes proliferation, secretion and invasion of fibroblast-like synoviocyte from rats with adjuvant induced arthritis.
Chang, Y; Jia, X; Sun, X; Xu, S; Wu, Y; Zhang, L; Wei, W
Mol Immunol. 2015 Mar;64(1):90-8. doi: 10.1016/j.molimm.2014.11.002. Epub 2014 Nov 23.
Applications: Measurement of Rat APRIL in synovium homogenate samples.
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